C H E E R I - O - E V E R Y - O N E

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February 28, 2013
RE: In response to a question about CO-E1/NADH/ENADH from a master herbologist:

"Hi Todd,

This would be a synthetic, of course - it appears to be what I would refer to as a Biologic. This basically means that it is attempting to mimic a substance in the body. This is similar to other items (Coenzyme-Q10, 5-MTHF/Metafolin, etc.) Biologics can be appropriate in very specific situations where there is a known genetic mutation that causes their production to become sluggish or nonexistent. By supplementing them, you can actually bypass the genetic mutation, making it as if it wasn't there at all.

Specifically in this case, NADH is the biologically active form of Vitamin B3 (Niacin) which is also carrying a Hydrogen atom with it. It may be appropriate for those who have defects in Niacin metabolism / enzymes in the body, like those who have folic acid metabolism enzyme (5-methyltetrahydrofolate / 5-MTFH) defects would take 5-MTHF, aka Metafolin.

Again, the only time that biologics are really warranted is with a known instance of a genetic defect. Otherwise, they do have the potential to cause a surplus in specific cyclic pathways, which can totally throw off the balance of other metabolic processes at large if there is no defect causing a deficiency, by causing part of the cycle to which they belong to run in overdrive. This can burn up surpluses of other nutrients and do more harm than good overall.

In all honesty, from my reading, it looks like one of the latest set of fad supplements. The scientific trials where it was tested so far only show inconclusive results at best for most of the items that people are looking to treat with it."

Source: A Master Herbologist

Niacin (also known as vitamin B3, nicotinic acid and vitamin PP) is an organic compound with the formula C6H5NO2 and, depending on the definition used, one of the 40 to 80 essential human nutrients.

Niacin is one of five vitamins (when lacking in human diet) associated with a pandemic deficiency disease: niacin deficiency (pellagra), vitamin C deficiency (scurvy), thiamin deficiency (beriberi), vitamin D deficiency (rickets and osteomalacia), vitamin A deficiency (night blindness and other symptoms). Niacin has been used for over 50 years to increase levels of HDL in the blood and has been found to modestly decrease the risk of cardiovascular events in a number of controlled human trials.[3]

This colorless, water-soluble solid is a derivative of pyridine, with a carboxyl group (COOH) at the 3-position. Other forms of vitamin B3 include the corresponding amide, nicotinamide ("niacinamide"), where the carboxyl group has been replaced by a carboxamide group (CONH2), as well as more complex amides and a variety of esters. Nicotinic acid and niacinamide are convertible to each other with steady world demand rising from 8500 tonnes per year in 1980s to 40,000 in recent years.[4]

Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to NAD and NADP in vivo. Nicotinic acid, nicotinamid, and tryptophan (via quinoline acid) are co-factors for nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD converts to NADP by phosphorylation in the presence of the enzyme NAD-kinase. NADP and NAD are coenzyme for many dehydrogenases, participating in many hydrogen transfer processes.[5] NAD is important in catabolism of fat, carbohydrate, protein and alcohol as well as cell signaling and DNA repair and NADP mostly in anabolism reaction such as fatty acid and cholesterol synthesis.[5] High energy requirements (brain) or high turnover rate (gut, skin) organs are usually the most susceptible to their deficiency.[6] Although the two are identical in their vitamin activity, nicotinamide does not have the same pharmacological effects (lipid modifying effects) as niacin. Nicotinamide does not reduce cholesterol or cause flushing.[7] Nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults.[8] Niacin is a precursor to NAD+/NADH and NADP+/NADPH, which play essential metabolic roles in living cells.[9] Niacin is involved in both DNA repair, and the production of steroid hormones in the adrenal gland.

Niacin is found in variety of foods, including liver, chicken, beef, fish, cereal, peanuts and legumes, and is also synthesized from tryptophan, an essential amino acid found in most forms of protein.

    Animal products:
  • liver, heart and kidney (9 – 15 mg niacin per 100 grams)
  • chicken, chicken breast (6.5 mg)
  • beef (5 – 6 mg)
  • fish: tuna, salmon, halibut (2.5 – 13 mg)
  • eggs (0.1 mg)
    Fruits and vegetables:
  • avocados (1 mg niacin per 100 grams)
  • dates (2 mg)
  • tomatoes (0.7 mg)
  • leaf vegetables (0.3 - 0.4 mg)
  • broccoli (0.6 mg)
  • carrots (0.3 - 0.6 mg)
  • sweet potatoes (0.5 - 0.6 mg)
  • asparagus (0.4 mg)
  • nuts (2 mg niacin per 100 grams)
  • whole grain products (4 - 29.5 mg)
  • legumes (0.4 – 16 mg)
  • saltbush seeds
  • mushrooms, shiitake mushrooms (3.5 – 4 mg niacin per 100 grams)
  • brewer's yeast (36 mg)
  • Monster Energy drink (40 mg per 16 ounces)
  • Rockstar Energy (100% in the Super Sours flavors)
  • Red Bull Energy Drink (28 mg per 12 ounces)
  • Five Hour Energy drink (30 mg per 1.93 ounces)
  • Ovaltine (18 mg)
  • Peanut butter (15 mg)
  • Tofu
  • Soy sauce (0.4 mg)
  • Vegemite (from spent brewer's yeast) (110 mg niacin per 100 grams)